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IgA Nephropathy

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  • Basics
  • Symptoms
  • Complications
  • Diet
  • Healthy living
  • Treatment

IgA nephropathy basics

IgA nephropathy is a kind of glomerulonephritis and it is characterized with immunoglobulin A (IgA) in mesangial area. Knowing the basic knowledge of IgA nephropathy can help the patients control the condition better.

Symptoms of IgA nephropathy

Hematuria is the most common symptom of IgA nephropathy. It can be divided into gross and microscopic hematuria. Microscopic hematuria is only visible with the acid of a microscope.Another common sign is feet and leg swelling.

As the condition progresses,more symptoms will appear including fatigue,nausea,swelling of hands and feet and high blood pressure,back pain and increased urination (especially at night).

Causes of IgA nephropathy

The causes of IgA nephropathy are not well understood. The disease seems to cluster in certain families and in certain areas of the world.In addition,infection, especially upper urinary tract infection can cause inflammatory reaction in body, resulting in secretion of inflammatory cytokines.The massive immune complexes accumulate in the mesangial area can cause inflammation in kidneys.

Diagnosis of IgA Nephropathy

The presence of blood or protein in the urine are possible sign of IgA nephropathy.A biopsy should be performed to confirm the diagnosis.A small piece of tissues is removed from the kidney and is examined under a microscope.

Prognosis of IgA nephropathy

Twenty to forty percent of the patients with IgA nephropathy will develop end stage renal disease (ESRD) about 20 years after the disease becomes apparent.When the disease is diagnosed,if the patients have increased creatinine level, they are more likely to develop chronic kidney failure. In general, high blood pressure and heavy protein in urine are associated with a poor prognosis.

Treatment for IgA nephropathy

Diet plays a vital role in treating IgA nephropathy. Limiting the amount of protein in the diet can help reduce protein leakage in urine.Careful control of high blood pressure can reduce strain on kidneys. In addition, fish oil supplement can help slow the loss of kidney function.

Some medications are used to control the symptoms of IgA nephropathy.When kidneys fail,Dialysis and kidney transplant will be used to sustain the patients’ life.

Immunotherapy is a new and effective treatment for IgA nephropathy.It can treat the disease from its underlying causes, thus controlling IgA nephropathy fundamentally.

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Symptoms of IgA Nephropathy

In early stage of IgA nephropathy,the patients usually experience no symptoms.The disease can go asymptomatically for decades.It is firstly suspected when protein and red blood cells are noticed in urine.However,with the progressive loss of renal function,signs and symptoms of IgA nephropathy will occur.

Cola or tea-colored urine

Cola or tea-colored urine is a typical sign of IgA nephropathy. It is due to loss of red blood cells in urine. The amount of blood may be so small that it is only visible with the acid of a microscope.

Repeated episodes of cola-or tea-colored urine, sometimes even visible blood in urine,usually during or after an upper respiratory or other type of infection.

Foamy urine

Foamy urine can occur in some cases of IgA nephropathy due to the leakage of heavy protein in urine.As glomeruli are impaired, they fail to prevent proteins from leaking into urine,thus resulting in proteinuria.Proteinuria is a significant accelerator in worsening renal function.

Swelling in hands and feet

Proteins in blood can hold fluid in blood vessels.Leakage of protein can lower the protein level in blood.Low levels of protein in blood can not hole the fluid.As a result,the fluid in blood vessels will infilter into subcutaneous tissue, thus resulting in swelling.

High blood pressure

High blood pressure occurs due to retention of excess fluid in body.In return,high blood pressure can cause stress on renal blood vessels, thus accelerating renal function deterioration.

Fatigue

Fatigue can occur in advanced stage of IgA nephropathy due to anemia.Healthy kidneys can produce a hormone called EPO.EPO can stimulate bone marrow to make red blood cells.However,the diseased kidneys fail to produce EPO,thus resulting in reduced number of red blood cells. Anemia can then contribute to fatigue.

Nausea

Nausea may occur as kidneys are impaired significantly.After kidneys are impaired,high levels of waste products build up in body.The waste products can irritate gastrointestinal tract, leading to nausea.

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Complications of IgA Nephropathy

The course of IgA nephropathy varies from individual to individual.Some people can live with the disease for years without problems.However,as the disease progresses,the patients may develop the following complications.

High blood pressure

Damage to kidneys from IgA deposits can raise your blood pressure.In return,high blood pressure can worsen renal function further.There is a vicious circle between high blood pressure and kidney damage.

High cholesterol

Loss of protein into urine can contribute to high cholesterol level.High levels of cholesterol may increase the risk of cardiovascular disease and a heart attack.

Nephrotic Syndrome

Nephrotic syndrome is a nonspecific disease.It is featured with heavy proteinuria,hypoproteinemia,high cholesterol and lipids, and swelling of your eyelids,feet and abdomen.

Chronic kidney failure

As IgA nephropathy,it can cause scarring of glomeruli.The kidneys will stop functioning gradually,resulting in chronic kidney failure.When kidneys fail, Dialysis or kidney transplant will be required to keep the patients alive.

Acute kidney failure

If the kidneys fail to filter waste products from body, waste products will build up quickly in blood quickly. In this case, acute kidney failure can occur.

Anemia

Anemia is a common complication of IgA nephropathy in its advanced stage.Healthy kidneys can produce a kind of hormone called EPO.EPO can stimulate bone marrow to make red blood cells.However,the diseased kidneys fail to produce EPO normally. As a result,less red blood cells are produced,thus resulting in anemia.If anemia occurs,the patients may have fatigue, dizziness and chill.

Cardiovascular disease

High blood pressure and high cholesterol can contribute to cardiovascular disease.Cardiovascular disease and heart disease are important death causes for patients with IgA nephropathy.

The above are the common complications of IgA nephropathy. If you want some ways to manage the complications, you can email to chinakidneytherapy@gmail.com.

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IgA Nephropathy Diet

A balanced diet can reduce the risk of developing kidney failure and death in IgA nephropathy.It is important for the patients to consult with a dietitian to make an individualized diet.What is a proper IgA nephropathy diet?

Restricted protein

A low-protein diet is necessary for people with IgA nephropathy. It can reduce the leakage of protein from body and lower stress on glomeruli.Thereby,it can slow down renal function deterioration remarkably.

Turn a vegetarian

Fatty acids are mediators of inflammation because of their ability to form compounds known as prostaglandins.There are good and bad prostaglandins and the good kind have anti-inflammatory effects.However,the bad kind fuel the fires.

A bad fatty acid is arachidonic acid,which is derived almost entirely from meat and dairy products.Additionally,animal foods are also high in saturated fats,which can also increase the inflammatory response in kidneys.Therefore, the patients with IgA nephropathy should eat less meat and dairy products,but increase the supplement of vegetables in their diet.

Fish oil

Fish oil is suggested to the patients with IgA Nephropathy due to omega-3 fatty acid in it.Omega-3 fatty acids are effective in controlling the inflammation in kidneys,thus slowing down renal function decline.Tuna, salmon and so on are good sources of fish oil.

Low sodium

It is important for the patients with IgA nephropathy to keep a low-sodium diet.If excess sodium is consumed,it can increase the retention of fluid and sodium.Retention of excess fluid in body can worsen high blood pressure and swelling.

Low-fat diet

The patients should keep a low-fat diet. This is because too much fat will be metabolized into lipid which can elevate blood viscosity and increase the risk of cardiovascular disease and heart disease.

The above are the general dietary suggestions for people with IgA nephropathy. For individualized diet plan, you can email to chinakidneytherapy@gmail.com.

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Healthy living for IgA nephropathy

Similar to other kidney disease,healthy living is an assistant for treatment.Many IgA sufferers are eager to find healthy living principles to keep kidney disease under control.Without suitable healthy living ,some IgA sufferers enters into kidney failure at fast speed.So let’s learn some healthy living tips together and hopefully solve your problems.

Have a good rest

Good rest means to create a better environment for kidney to absorb nutritious and impair kidney structure.In order to slow down the progression of kidney disease,IgA sufferers avoid overworking and strenuous exercises.

Avoid infections

Most IgA sufferers have abnormal immune system or lower immunity.There are many bacteria and vinous around us.When our immune system decrease the ability to protect our body,harmful substances begins to invade our body.Therefore inflammatory response occurs so as to protecting our body.With normal immune system,people have inflammatory response for a period and stops when harmful substances stop their invasion.But IgA sufferers with abnormal immune system fails to stop inflammatory response timely and keep continuous inflammatory thus leading to producing more immune complex.Hence,more and more immune complex deposits in the kidney thus leading to further kidney damage.

Control high blood pressure

Food with high fat and high sugar are usually found on the table,plus many IgA sufferers ignores diets they have everyday.Hence high blood pressure occurs.While high blood pressure aggravates kidney damage and kidney damage affects high blood pressure in the same way.Because high blood pressure can lead to many complications which threatens sufferer’s life seriously,sufferers need to go to hospital to test blood pressure regularly.

Medicine

Many medicines do harmful for kidney that kidney begin to be poisoned.Hence kidney disease develops into end-stage renal disease at fast speed

If you are diagnosed with IgA ,you can get more specific healthy living suggestions by emailing to chinakidneytherapy@gmail.com and also find individual therapies.

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IgA Nephropathy Treatment

IgA nephropathy is an autoimmune disorder with immune globulin A (IgA) in mesangial area.As the glomeruli become inflamed and scarred,renal function will keep declining progressively.What is the treatment for IgA nephropathy?

Immunotherapy

Immunotherapy is a new and effective treatment for IgA nephropathy.It can treat IgA nephropathy from its underlying causes,controlling the disease completely and fundamentally.

Immunotherapy can be divided into six steps including exact diagnosis,immune blocking,immune tolerance,immune adjustment, immune clearance and immune protection.These six treatment steps can cooperate closely to treat IgA nephropathy fundamentally and completely.

Micro-Chinese Medicines Osmotherapy

Micro-Chinese Medicines Osmotherapy is an externally applied therapy for IgA nephropathy based on traditional Chinese herbal medicine.As the therapy does not contain any chemical drugs,it has no adverse effects on body at all.

Based on the patients’ illness condition,specific herbal medicines will be applied in the therapy.This therapy can treat IgA nephropathy effectively by correcting the immune dysfunction and rebuilding normal immune system.

Steroid

Steroid therapy is the mostly often applied therapy for IgA nephropathy.It can suppress the inflammatory response in kidneys to bring about a remission.However,it can not stop renal function decline.What’s worse,long-term use of steroid can cause a large number of adverse effects on body.

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